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Source Escherichia coli
Amino Acid Sequence
Species Escherichia coli
Sequence MGSSHHHHHHSSGLVPRGSHMGSHMSIKEQTLMTPYLQFDRNQWAALRDS VPMTLSEDEIARLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVL EQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRRVELITT DGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYS HLIYDVIPDGDKTVVQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFS IYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFHNYAKLTKEEAIKTAMT LWKEINWLNLKQNILPTRERASLI
Molecular weight 39 kDa including tags
Amino acids 1 to 316
Tags His tag N-Terminus Specifications
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity > 95
% SDS-PAGE. ab123146 was purified using conventional chromatography.
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 0.03% DTT, 0.32% Tris HCl, 10% Glycerol, 1.17% Sodium chloride
Function Plays a role in the physiological regulation of the intracellular CoA concentration.
Tissue specificity Isoform 1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.
Pathway Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Sequence similarities Belongs to the type II pantothenate kinase family.
Domain The N-terminal extension, present in isoform 1 may be the regulatory domain.
Cellular localization Cytoplasm.
Information by UniProt
E. coli PANK1 protein images
References for Recombinant
E. coli PANK1 protein (ab123146)
has not yet been referenced specifically in any publications.
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