Recombinant Guinea pig HRH1 protein (ab90420)

Overview

Description

  • NatureRecombinant
  • SourceInsect cells
  • Amino Acid Sequence
    • SpeciesGuinea pig

Specifications

Our Abpromise guarantee covers the use of ab90420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

  • FormLiquid
  • Additional notes


    Small HRH1 agonists exhibit similar effects at Human HRH1 and guinea pig HRH1, whereas bulkier 2-phenylhistamines and histaprodifens are up to ~10-fold more potent at guinea pig HRH1 than at Human HRH1. Several first-generation HRH1 antagonists are ~2-fold, and arpromidine-type HRH1 antagonists up to ~10-fold more potent at guinea pig HRH1 than at Human HRH1.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

General Info

  • Alternative names
    • BPHS, mouse, homolog of
    • H1 R
    • H1R
    • HH1R
    • HisH1
    • Histamine H(1) receptor
    • Histamine H1 receptor
    • Histamine receptor H1
    • Histamine receptor subclass H1
    • Hrh1
    • HRH1_HUMAN
    see all
  • FunctionIn peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in regulating signal transduction through the receptor molecule.
  • Cellular localizationCell membrane.
  • Information by UniProt

References for Recombinant Guinea pig HRH1 protein (ab90420)

ab90420 has not yet been referenced specifically in any publications.

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