Recombinant Hepatitis B Virus Core Antigen protein (ab49014)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Amino acids
      1 to 144
    • Additional sequence information
      Deleted DNA binding domain. Fully competent for self-assembly.

Specifications

Our Abpromise guarantee covers the use of ab49014 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Reacts strongly with human HBV positive serum.
  • Applications

    Western blot

    ELISA

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Additional notes


    During infection, the C gene of HBV often displays genetic deletions within the tip of the protruding spikes of HBcAg, which are known to contain the major site for antibody binding . These have been referred to as core internal deletion variants, and they often appear in end stage liver disease. Depending on the nature of the deletion, they may still form functional capsids,

    Reacts strongly with human HBV positive serum.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 75mM Sodium chloride, 7.5mM PBS, pH 7.2

General Info

  • Alternative names
    • C
    • Capsid protein
    • core
    • Core and e antigen
    • Core antigen
    • Core protein
    • HBc
    • HBcAg
    • HBVgp4
    • Hepatitis B core antigen
    • Hepatitis B Virus core antigen
    • p21.5
    • precore/core protein
    see all
  • Relevance
    Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.
  • Cellular localization
    Capsid protein: Virion. Host cytoplasm, hepatocyte nucleus.

References

ab49014 has not yet been referenced specifically in any publications.

Publishing research using ab49014? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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1 Review or Q&A

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Votes: Highest First

I am looking for HBV core antigen of different genotype. I saw you have several product listed on your website, but they do not have genotype information. Could you please let me know the genotype of each of these? Or a sequence would work too.

All three of the core antigen proteins you asked about are from the HBV320 strain, genotype D. The article at this URL, https://www.ncbi.nlm.nih.gov/pubmed/?term=8336122, identifies the genotype of HBV320 and many other strains in Figures 1 and 2.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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