Recombinant Hepatitis B Virus Core Antigen protein (ab49014)
- Datasheet
- Specific References
- Protocols
Overview
- Product nameRecombinant Hepatitis B Virus Core Antigen protein
See all Hepatitis B Virus Core Antigen proteins and peptides - Protein lengthProtein fragment
Description
- NatureRecombinant
- SourceEscherichia coli
- Amino Acid Sequence
- Amino acids1 to 144
- Additional sequence informationDeleted DNA binding domain. Fully competent for self-assembly.
Specifications
Our Abpromise guarantee covers the use of ab49014 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Biological activityReacts strongly with human HBV positive serum.
- Applications
Western blot
ELISA
- Purity> 95
% SDS-PAGE.
- FormLiquid
- Additional notes
During infection, the C gene of HBV often displays genetic deletions within the tip of the protruding spikes of HBcAg, which are known to contain the major site for antibody binding . These have been referred to as core internal deletion variants, and they often appear in end stage liver disease. Depending on the nature of the deletion, they may still form functional capsids,
Reacts strongly with human HBV positive serum. -
Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: None
Constituents: 50% Glycerol, 75mM Sodium chloride, 7.5mM PBS, pH 7.2
General Info
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Alternative names
- C
- Capsid protein
- Core and e antigen
see all - RelevanceHepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.
- Cellular localizationCapsid protein: Virion. Host cytoplasm, hepatocyte nucleus.
References for Recombinant Hepatitis B Virus Core Antigen protein (ab49014)
ab49014 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"