The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityReacts strongly with human HBV positive serum.
During infection, the C gene of HBV often displays genetic deletions within the tip of the protruding spikes of HBcAg, which are known to contain the major site for antibody binding . These have been referred to as core internal deletion variants, and they often appear in end stage liver disease. Depending on the nature of the deletion, they may still form functional capsids,
Reacts strongly with human HBV positive serum.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
RelevanceHepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection.
The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.