Recombinant Hepatitis C Virus Core 1a protein (ab67718)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Amino acids
      2 to 119
    • Tags
      His tag C-Terminus
    • Additional sequence information
      Recombinant fragment, corresponding to N terminal amino acids 2-119 of Hepatitis C Virus Core protein, genotype 1a; containing core nucleocapsid immunodominant region.

Specifications

Our Abpromise guarantee covers the use of ab67718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    This protein is immunoreactive with sera of HCV-infected individuals.
  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    This protein is >95% pure as determined by 10% PAGE (coomassie staining). It was purified by proprietary chromatographic techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl, 50% Glycerol, 9% Urea, 0.2% Triton-X-100

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Capsid protein C
    • HCV 1a nucleocapsid
    • HCV core 1a
    • HCV core protein genotype 1a
    • Hepatitis C Virus core protein
    • p21 , p19
    see all
  • Relevance
    HCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.
  • Cellular localization
    Host endoplasmic reticulum membrane; Single-pass membrane protein. Host mitochondrion membrane; Single-pass type I membrane protein. Host lipid droplet. Host cytoplasm. Host nucleus. Secreted

References

ab67718 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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