The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThis protein is immunoreactive with sera of Hepatitis C Virus-infected individuals.
The HCV Core 24 genotype-1b, E.coli derived recombinant protein, contains the HCV core nucleocapsid immunodominant regions. The protein is fused with b-galactosidase (114 kDa) at N-terminus.
% by SDS-PAGE. Hepatitis C Virus Core 24 protein was purified by a proprietary chromatographic technique.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
HCV core 24
Hepatitis C virus core protein
RelevanceHepatitis C Virus (HCV) is a small 50nm, enveloped, single-stranded, positive sense RNA virus in the family Flaviviridae.
HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes (1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
References for Recombinant Hepatitis C Virus Core 24 protein (ab67735)
has not yet been referenced specifically in any publications.
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