Recombinant Hepatitis C Virus Core 3a protein (ab123527)


  • Product nameRecombinant Hepatitis C Virus Core 3a protein
  • Protein lengthProtein fragment


  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ81258
    • Molecular weight23 kDa
    • Amino acids1 to 216


Our Abpromise guarantee covers the use of ab123527 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityOne unit of protease hydrolyzes 1 picomole of Ac-Asp-Glu-Dap(QXL™520)- Glu-Glu-Abu-COO-Ala -Ser-Cys(5-FAMsp)-NH2 per minute at pH 7.5 at 25° C.
    ab123527 is in active form and the pre-activation by pep4A or pep4AK is not necessary.
  • Applications

    Functional Studies

  • FormLiquid
  • Additional notes

    NS3 protease of hepatitis C virus (HCV), located on the N-terminal domain of HCV NS3, is responsible for the cleavage at the NS3/NS4A, NS4A/NS4B, NS4B/NS5A, and NS5A/NS5B sites of the nonstructural protein. The HCV NS3 is a chymotrypsin-like serine protease. It requires a cofactor, a 54 amino acid NS4 protein, to reach its optimal activity. The X-ray crystal structure studies show that NS3 forms a tight non-covalent complex with NS4. The NS3/4A protease is essential for viral replication and the formation of infectious viral particles.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.75% Potassium chloride, 0.003% DTT, 0.32% Tris HCl, 0.06% EDTA, 20% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • HCV 3a
    • HCV Core 3a
    • HCV Core genotype 3a
    • HCV3a
    • Hepatitis C Virus Core genotype 3a
    see all
  • RelevanceHCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.

References for Recombinant Hepatitis C Virus Core 3a protein (ab123527)

ab123527 has not yet been referenced specifically in any publications.

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