This product is an active protein and may elicit a biological response in vivo, handle with caution.
Hepatitis virus NS5A
Non structural protein 5A
RelevanceHCV is classified into the genus Hepacivirus of the family Flaviviridae. Like all the members of the family, HCV is an enveloped, single-stranded, positive-sense RNA virus. Its genome (about 9600 nt) is flanked at both termini by conserved, highly structured non-translated regions (NTRs) and encodes a polyprotein precursor (about 3000 aa), which is proteolytically processed by host and viral proteases to produce the structural (core, E1, E2 and p7) and non-structural (NS2, NS3, NS4A, NS4B, NS5A and NS5B) proteins of the virus. Recently, an additional protein has been identified, whose function remains unknown.
HCV is a major cause of acute hepatitis and chronic liver disease, including cirrhosis and liver cancer. Currently, no vaccine is currently available to prevent hepatitis C, and therapeutic approaches to treatment are still limited.
NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008).
NS5B RNA-dependant RNA polymerase is responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication.
References for Recombinant Hepatitis C Virus genotype 2a NS5 protein (ab68374)
has not yet been referenced specifically in any publications.
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