Recombinant HIV tat (mutated C31 A + C34 A) protein (ab119447)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence

Specifications

Our Abpromise guarantee covers the use of ab119447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C.

    Constituent: 0.1% Glycerol

  • Reconstitutionab119447 should be reconstituted in apirogenic sterile water or PBS buffer. Reconstituted protein should be used immediately.

General Info

  • Alternative names
    • p14
    • Tat
    • Tat protein
    • Transactivating regulatory protein
  • RelevanceThe transcriptional transactivator (Tat) is a key regulatory protein of HIV. It is expressed early after the virus integrates into the cell, and stimulates the elongation of RNA polymerase II. It binds onto a sequence known as the TAR, or transactivator response element, located at the end of the HIV genetic chain. There, the tat protein helps assemble new copies of HIV. The tat protein-TAR complex speeds up the rate of viral reproduction by about a thousand times. If it is not present, the transcription process frequently stops short, and few functional HIV particles are produced. Tat is an important potential target for antiretrovirals and vaccine development.

References for Recombinant HIV tat (mutated C31 A + C34 A) protein (ab119447)

ab119447 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab119447.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"