Recombinant HIV2 gp36 protein (Beta-Galactosidase) (ab49057)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • Additional sequence informationFused with β-galactosidase at the N-terminus.

Specifications

Our Abpromise guarantee covers the use of ab49057 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityReacts strongly with human HIV positive sera.
  • Applications

    ELISA

    Western blot

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Additional notesReacts strongly with human HIV positive sera.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 0.05% Tween 20, 0.014M Beta mercaptoethanol, 0.01M Sodium carbonate, 0.01M EDTA

General Info

  • Alternative names
    • Gp36
    • HIV 2
    • Human immunodeficiency virus 2
  • RelevanceHIV2 infections at present, are predominantly found in west Africa where it is the dominant form of HIV. Both HIV1 and HIV2 have the same modes of transmission and are associated with similar opportunistic infections and AIDS. In persons infected with HIV2, immunodeficiency seems to develop more slowly and to be milder, but as the disease advances, HIV2 infectiousness seems to increase. Little is known about the best approach to the clinical treatment and care of patients infected with HIV2. Some drugs used to treat HIV1 are ineffective. HIV1 and HIV2 have similar gag (viral core) and pol (polymerase) regions, they have relatively dissimilar env (envelope) regions. Owing to this lack of homology in the envelope region, there is little serologic cross-reactivity of the antibodies directed against the envelope antigens of both HIV1 and HIV2. The env gp36 ectodomain is highly conserved and elicits a type-specific antibody response. Hence, most licensed diagnostic assays incorporate gp36-derived antigens to detect HIV2 specific antibodies. It is becoming important to differentiate between single infection with either HIV1 or HIV2 and dual infection.

References for Recombinant HIV2 gp36 protein (Beta-Galactosidase) (ab49057)

ab49057 has not yet been referenced specifically in any publications.

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