ReconstitutionPlease reconstitute with 500ul sterile water for a concentration of 1 mg/ml.
14 3 3 protein beta/alpha
14-3-3 protein beta/alpha
Brain protein 14 3 3 beta isoform
Epididymis secretory protein Li 1
HEL S 1
Protein kinase C inhibitor protein 1
Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide
FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.
Sequence similaritiesBelongs to the 14-3-3 family.
Post-translational modificationsThe alpha, brain-specific form differs from the beta form in being phosphorylated. Isoform Short contains a N-acetylmethionine at position 1.
Cellular localizationCytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.