Recombinant Human 14-3-3 sigma protein (ab40599)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS
    • Molecular weight
      28 kDa
    • Tags
      His tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab40599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.002% Sodium Azide
    Constituents: 3mM Sodium chloride, 10mM Tris, 2.5mM Imidazole, pH 8

General Info

  • Alternative names
    • 14 3 3 protein sigma
    • 14-3-3 protein sigma
    • 1433S_HUMAN
    • Epithelial cell marker protein 1
    • Er
    • HME 1
    • HME1
    • MGC143283
    • Mkrn3
    • Mme1
    • OTTHUMP00000004242
    • RP23 137L22.11
    • SFN
    • SFN protein
    • Stratifin
    • YWHAS
    see all
  • Function
    Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
    p53-regulated inhibitor of G2/M progression.
  • Tissue specificity
    Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
  • Sequence similarities
    Belongs to the 14-3-3 family.
  • Post-translational
    modifications
    Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
  • Cellular localization
    Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
  • Information by UniProt

Recombinant Human 14-3-3 sigma protein images

  • Analysis of 14-3-3 sigma Recombinant protein. 4-20% SDS gradient gel. Coomassie blue staining. Band size approximately 28 kDa.

References for Recombinant Human 14-3-3 sigma protein (ab40599)

ab40599 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab40599.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up