Recombinant Human 67kDa Laminin Receptor protein (ab112316)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP08865
    • SpeciesHuman
    • SequenceEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEV ADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS
    • Molecular weight37 kDa including tags
    • Amino acids196 to 295
    • TagsGST tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab112316 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    Peptide Array

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
    Note: Glutathione is reduced.

General Info

  • Alternative names
    • 34/67 kDa laminin receptor
    • 37 kDa laminin receptor precursor
    • 37/67 kDa laminin receptor
    • 37LRP
    • 40S ribosomal protein SA
    • 67 kDa laminin receptor
    • 67LR
    • Colon carcinoma laminin binding protein
    • Colon carcinoma laminin-binding protein
    • LAMBR
    • Laminin receptor 1
    • Laminin-binding protein precursor p40
    • LamR
    • LAMR 1
    • LAMR1
    • LBP
    • LBP/p40
    • LRP
    • LRP/LR
    • Multidrug resistance associated protein MGr1 Ag
    • Multidrug resistance associated protein MGr1Ag
    • Multidrug resistance-associated protein MGr1-Ag
    • NEM/1CHD4
    • p40
    • Ribosomal Protein SA
    • rpsA
    • RSSA_HUMAN
    • SA
    see all
  • FunctionRequired for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
  • Sequence similaritiesBelongs to the ribosomal protein S2P family.
  • Post-translational
    modifications
    Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
    Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
  • Cellular localizationCell membrane. Cytoplasm. Nucleus. 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell membrane.
  • Information by UniProt

Recombinant Human 67kDa Laminin Receptor protein images

  • ab112316 on a 12.5% SDS-PAGE Stained with Coomassie Blue

References for Recombinant Human 67kDa Laminin Receptor protein (ab112316)

ab112316 has not yet been referenced specifically in any publications.

Product Wall

Regarding your enquiry about Human 67kDa Laminin Receptor protein fragment, ab112316, I am sorry but we have not determined the molar extinction coefficient of the product.
As it contains reduced Glutathione in the storage buffer, we quantify its c...

Read More

Thank you for your email and interest in Abcam products. ab112316 is only a fragment of the Laminin Receptor protein (UniProt P08865). It consists of 100 amino acids (position 196-295) and an additional tag. Therefore, the predicted molecular weigh...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"