The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 28.8% Guanidine HCl
ReconstitutionReconstitute with water to desired concentration.
ATP binding cassette protein
ATP binding cassette sub family B (MDR/TAP) member 5
ATP binding cassette sub family B member 5
ATP-binding cassette sub-family B member 5
P glycoprotein ABCB5
FunctionPlasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.
Tissue specificityExpressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.