The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 µg/µl.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
2' 5' oligoadenylate binding protein
2'5' oligoadenylate binding protein
ATP binding cassette sub family E (OABP) member 1
ATP binding cassette sub family E member 1
ATP-binding cassette sub-family E member 1
Ribonuclease 4 inhibitor
Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor
Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor
Ribonuclease L inhibitor
RNase L inhibitor
FunctionAntagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Sequence similaritiesBelongs to the ABC transporter superfamily. ABCE family. Contains 2 4Fe-4S ferredoxin-type domains. Contains 2 ABC transporter domains.
Cellular localizationCytoplasm. Mitochondrion. Localized to clusters of virus formation at the plasma membrane.