Overview

  • Product name
    Recombinant Human ABI2 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      27 kDa including tags
    • Amino acids
      29 to 268
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names
    • Abelson interactor 2
    • ABI 2
    • Abi-2
    • ABI2
    • ABI2_HUMAN
    • ABI2B
    • Abl binding protein 3
    • Abl interacting protein 1 (SH3 containing protein)
    • Abl interactor 2
    • Abl interactor protein 2b
    • Abl-binding protein 3
    • AblBP3
    • AIP 1
    • Arg binding protein 1
    • Arg protein tyrosine kinase binding protein
    • Arg-binding protein 1
    • ArgBP1
    • ARGBPIA
    • ArgBPIB
    • OTTHUMP00000163783
    • OTTHUMP00000163784
    • OTTHUMP00000206182
    • OTTHUMP00000206183
    • OTTHUMP00000206184
    • OTTHUMP00000206185
    • SSH3BP2
    see all
  • Function
    May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
  • Sequence similarities
    Belongs to the ABI family.
    Contains 1 SH3 domain.
    Contains 1 t-SNARE coiled-coil homology domain.
  • Post-translational
    modifications
    Is a substrate for ABL1.
  • Cellular localization
    Cytoplasm and Cell projection > lamellipodium. Cell projection > filopodium. Cytoplasm > cytoskeleton. Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips.
  • Information by UniProt

References

ab127336 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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