Recombinant human active Caspase 2 protein (ab52098)

Overview

  • Product nameRecombinant human active Caspase 2 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab52098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySPECIFIC ACTIVITY: 10,000 – 13,000 units/mg UNIT DEFINATION: One unit of the recombinant caspase-2 is the enzyme activity that cleaves 1 nmol of the caspase substrate VDVAD-pNA (pNA: pnitroanaline) per hour at 37oC in a reaction solution containing 50 mM Hepes, pH 7.2, 50 mM NaCl, 0.1% Chaps, 10 mM EDTA, 5% Glycerol, and 10 mM DTT
  • Applications

    Western blot

    SDS-PAGE

    Functional Studies

  • Purity> 95 % SDS-PAGE.

  • FormLyophilised
  • Additional notesThe lyophilized caspase-2 is stable for 1 year at –70oC.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 15% Glycerol, PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionReconstitute to 1 unit per µl in PBS containing 15% glycerol.

General Info

  • Alternative names
    • CASP2
    • Caspase 2
    • ICH 1L
    • ICH1
    • ICH1 protease
    • ICH1L
    • NEDD 2 apoptosis regulatory gene
    • NEDD2
    see all
  • RelevanceCaspase 2 is involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. During apoptosis, procaspase-2 is processed at aspartate residues. The processed form of caspase-2 consists of large (19 kDa) and small (12 kDa) subunits which associate to form the active enzyme.
  • Cellular localizationCytosol, membrane

References for Recombinant human active Caspase 2 protein (ab52098)

ab52098 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"