This product is an active protein and may elicit a biological response in vivo, handle with caution.
Activin A receptor type 1B
Activin A receptor type II like kinase 4
Activin A type 1B receptor
Activin A type IB receptor
Activin receptor like kinase 4
Activin receptor type 1B
Activin receptor type IB
Activin receptor type-1B
Activin receptor-like kinase 4
Serine(threonine) protein kinase receptor R2
Serine/threonine-protein kinase receptor R2
FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
Tissue specificityExpressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.