This product is an active protein and may elicit a biological response in vivo, handle with caution.
Adenylate cyclase inhibiting G alpha protein
Adrenergic beta 2 receptor surface
beta 2 adrenoceptor
Beta 2 adrenoreceptor
Beta subunit signal transducing proteins GS/GI
G gamma I
G protein beta 1 subunit
GTP binding regulatory protein Gi alpha 2 chain
Guanine nucleotide binding protein beta 1 subunit
Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 2
Guanine nucleotide binding protein gamma 2
Transducin beta chain 1
ADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
The G protein family of signal transducers includes 5 heterotrimers, which are most clearly distinguished by their different alpha chains; they have virtually identical beta chains and similar gamma chains. G protein alpha inhibitor chain 2 is a subunit of the G(i) G protein, whose role is in inhibiting adenylate cyclase activity in response to bound GTP. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.
GNB1 is a beta subunit. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
ADBR2 and ?1: Cell Membrane
Gia2: Plasma Membrane
References for Recombinant human ADBR2 + Gia2 fusion co-expressed with ß1 and ?1 protein (ab90755)
has not yet been referenced specifically in any publications.
Publishing research using ab90755? Please let us know so that we can cite the reference in this datasheet.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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