Recombinant human ADBR2 + Gia2 fusion protein (ab90752)

Overview

  • Product name
    Recombinant human ADBR2 + Gia2 fusion protein
  • Protein length
    Full length protein
  • Description
    Recombinant human ADBR2 + Giα2 fusion protein

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      90 kDa
    • Additional sequence information
      Tagged at the N terminus of the ADBR2 with a DDDDK tag. The C terminus of the ADBR2 is linked to the N terminus of the Gi alpha 2 with a His tag.

Specifications

Our Abpromise guarantee covers the use of ab90752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Activity: 4-15 pmol/mg.
  • Applications

    Functional Studies

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Adenylate cyclase inhibiting G alpha protein
    • ADRB2
    • ADRB2R
    • ADRBR
    • Adrenergic beta 2 receptor surf
    • B2AR
    • BAR
    • beta 2 adrenoceptor
    • Beta 2 adrenoreceptor
    • BETA2AR
    • Catecholamine receptor
    • GIP
    • GNAI 2
    • GNAI2B
    • GTP binding regulatory protein Gi alpha 2 chain
    • Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 2
    • H LUCA15.1
    • H LUCA16.1
    • WUGSC:H LUCA15.1
    • WUGSC:H LUCA16.1
    see all
  • Relevance
    ADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. The G protein family of signal transducers includes 5 heterotrimers, which are most clearly distinguished by their different alpha chains; they have virtually identical beta chains and similar gamma chains. G protein alpha inhibitor chain 2 is a subunit of the G(i) G protein, whose role is in inhibiting adenylate cyclase activity in response to bound GTP. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.
  • Cellular localization
    ADBR2: Cell Membrane

References

ab90752 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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