This product is an active protein and may elicit a biological response in vivo, handle with caution.
Adenylate cyclase inhibiting G alpha protein
Adrenergic beta 2 receptor surf
beta 2 adrenoceptor
Beta 2 adrenoreceptor
GTP binding regulatory protein Gi alpha 2 chain
Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 2
RelevanceADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
The G protein family of signal transducers includes 5 heterotrimers, which are most clearly distinguished by their different alpha chains; they have virtually identical beta chains and similar gamma chains. G protein alpha inhibitor chain 2 is a subunit of the G(i) G protein, whose role is in inhibiting adenylate cyclase activity in response to bound GTP. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.
Cellular localizationADBR2: Cell Membrane
References for Recombinant human ADBR2 + Gia2 fusion protein (ab90752)
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