Recombinant human ADBR2 + Gia3 fusion protein (ab90750)

Overview

  • Product name
    Recombinant human ADBR2 + Gia3 fusion protein
  • Protein length
    Full length protein
  • Description
    Recombinant human ADBR2 + Giα3 fusion protein

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      90 kDa
    • Additional sequence information
      Tagged at the N terminus of the ADBR2 with a DDDDK tag. The C terminus of the ADBR2 is linked to the N terminus of the Gi alpha 3 with a His tag.

Specifications

Our Abpromise guarantee covers the use of ab90750 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Activity: 7.6 pmol/mg.
  • Applications

    Functional Studies

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • ADRB2
    • ADRB2R
    • ADRBR
    • Adrenergic beta 2 receptor surface
    • B2AR
    • BAR
    • beta 2 adrenoceptor
    • Beta 2 adrenoreceptor
    • BETA2AR
    • Catecholamine receptor
    • G(i) alpha 3
    • Guanine nucleotide binding protein G(k) subunit alpha
    see all
  • Relevance
    ADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Gia3 (GNAI3) is the alpha subunit of inhibitory trimeric G protein (Gi), which inhibits adenylate cyclase once its G protein coupled receptors (GPCR) such as a2 adrenergic receptors are activated. GNAI3 can be inactivated by pertussis toxin. Guanine nucleotide binding proteins are involved as modulators or transducers in various transmembrane signaling systems. Gia3 is the stimulatory G protein of receptor-regulated K+ channels.
  • Cellular localization
    ADBR2: Cell Membrane

References

ab90750 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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