This product is an active protein and may elicit a biological response in vivo, handle with caution.
Adrenergic beta 2 receptor surface
beta 2 adrenoceptor
Beta 2 adrenoreceptor
G(i) alpha 3
Guanine nucleotide binding protein G(k) subunit alpha
RelevanceADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Gia3 (GNAI3) is the alpha subunit of inhibitory trimeric G protein (Gi), which inhibits adenylate cyclase once its G protein coupled receptors (GPCR) such as a2 adrenergic receptors are activated. GNAI3 can be inactivated by pertussis toxin. Guanine nucleotide binding proteins are involved as modulators or transducers in various transmembrane signaling systems. Gia3 is the stimulatory G protein of receptor-regulated K+ channels.
Cellular localizationADBR2: Cell Membrane
References for Recombinant human ADBR2 + Gia3 fusion protein (ab90750)
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