Recombinant human ADBR2 + GsaL Leu227 Asn295 fusion protein (ab90833)

Overview

  • Product nameRecombinant human ADBR2 + GsaL Leu227 Asn295 fusion protein
  • Protein lengthFull length protein
  • Description
    Recombinant human ADBR2 + GsαL Leu227 Asn295 fusion protein

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • Molecular weight104 kDa
    • Additional sequence informationTagged at the N terminus of the ADBR2 with a DDDDK tag. The C terminus of the ADBR2 is linked to the N terminus of the Gs alpha L with a His tag.

Specifications

Our Abpromise guarantee covers the use of ab90833 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityActivity: 3.7 pmol/mg.
  • Applications

    Functional Studies

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Adenylate cyclase stimulating G alpha protein
    • ADRB2
    • ADRB2R
    • ADRBR
    • Adrenergic beta 2 receptor surface
    • B2AR
    • BAR
    • beta 2 adrenoceptor
    • Beta 2 adrenoreceptor
    • BETA2AR
    • Catecholamine receptor
    • GNAS
    • Guanine nucleotide binding protein G(s) alpha subunit
    see all
  • RelevanceADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. GTP-binding proteins (G-proteins)are a family of heterotrimeric proteins that play a critical role in signal transduction by coupling cell surface, 7-transmembrane domain receptors to intracellular signaling pathways including second messenger generation (such as cyclic AMP, calcium and diacylglycerol), protein phosphorylation, ion channel activation, gene induction, cell growth and differentiation. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit.
  • Cellular localizationADBR2: Cell Membrane

References for Recombinant human ADBR2 + GsaL Leu227 Asn295 fusion protein (ab90833)

ab90833 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"