Recombinant human ADBR2 + GsaS-Leu212-Asn280 fusion protein (ab90336)

Overview

  • Product name
    Recombinant human ADBR2 + GsaS-Leu212-Asn280 fusion protein
  • Protein length
    Full length protein
  • Description
    Recombinant human ADBR2 + GsαS-Leu212-Asn280 fusion protein

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      98 kDa
    • Additional sequence information
      Tagged at the N terminus of the ADBR2 with a DDDDK tag. The C terminus of the ADBR2 is linked to the N terminus of the Gs alpha S Leu212 Asn280 with a His tag.

Specifications

Our Abpromise guarantee covers the use of ab90336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Activity: 1.4 - 5.7 pmol/mg.
  • Applications

    Functional Studies

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Adenylate cyclase stimulating G alpha protein
    • ADRB2R
    • AHO
    • B2AR
    • Beta 2 adrenergic receptor
    • Beta 2 adrenoceptor
    • C20orf45
    • dJ309F20.1.1
    • dJ806M20.3.3
    • Extra large alphas protein
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms short
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas
    • Guanine nucleotide regulatory protein
    • MGC33735
    • PHP1A
    • PHP1B
    • POH
    • Secretogranin VI
    • XLalphas
    see all
  • Relevance
    ADBR2 is a member of the G protein coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L type calcium channel Ca(V)1.2. This receptor channel complex also contains a G protein, an adenylyl cyclase, cAMP dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
  • Cellular localization
    ADBR2: Cell membrane; Multi-pass membrane protein.

References

ab90336 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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