Recombinant human ADRB2 + G16a fusion protein (ab90339)

Overview

  • Product name
    Recombinant human ADRB2 + G16a fusion protein
  • Protein length
    Full length protein
  • Description
    Recombinant human ADRB2 + G16α fusion protein

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      90 kDa
    • Additional sequence information
      Tagged at the N terminus of the ADRB2 with a DDDDK tag. The C terminus of the ADRB2 is linked to the N terminus of the G16 alpha with a His tag.

Specifications

Our Abpromise guarantee covers the use of ab90339 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Receptor expression level: 5.5 pmol/mg

  • Applications

    Functional Studies

  • Form
    Liquid
  • Additional notes
    Receptor expression level: 5.5pmol/mg.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • ADRB2
    • ADRB2R
    • ADRBR
    • Adrenergic beta 2
    • B2AR
    • BAR
    • beta 2 adrenoceptor
    • BETA2AR
    • Catecholamine receptor
    • G alpha 15
    • G alpha 16
    • G protein subunit alpha 15
    • G-protein subunit alpha 16
    • GNA15
    • GNA16
    • Gq class
    • Guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
    • Guanine nucleotide binding protein subunit alpha 16
    • Guanine nucleotide-binding protein subunit alpha 15
    see all
  • Relevance
    Beta 2 Adrenergic Receptor is a member of the G protein coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L type calcium channel Ca(V)1.2. This receptor channel complex also contains a G protein, an adenylyl cyclase, cAMP dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. This protein is the only heterotrimic G protein with a restricted expression pattern in haematopoietic cells. Differentiation of promyelocytic cells leads to decreased expression of G alpha 16. It also serves as a marker for haematopoietic progenitor cells.
  • Cellular localization
    ADRB2: Cell Membrane G16a: Plasma membrane

References

ab90339 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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