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Adrenergic beta 2
beta 2 adrenoceptor
G alpha 15
G alpha 16
G protein subunit alpha 15
G-protein subunit alpha 16
Guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Guanine nucleotide binding protein subunit alpha 16
Guanine nucleotide-binding protein subunit alpha 15
Beta 2 Adrenergic Receptor is a member of the G protein coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L type calcium channel Ca(V)1.2. This receptor channel complex also contains a G protein, an adenylyl cyclase, cAMP dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. This protein is the only heterotrimic G protein with a restricted expression pattern in haematopoietic cells. Differentiation of promyelocytic cells leads to decreased expression of G alpha 16. It also serves as a marker for haematopoietic progenitor cells.
ADRB2: Cell Membrane
G16a: Plasma membrane
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