Additional sequence informationDDDDK tagged N terminus of ADRB2. ADRB2 C terminus linked to the N terminus of the GsaL with His tag. This fusion protein contains a thrombin cleavage site (TS) between the His tag and GsaL subunit.
Guanine nucleotide binding protein G(s) subunit alpha isoforms short
Guanine nucleotide regulatory protein
RelevanceADRB2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. ADRB2 binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli.
Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses.
GsaL is the long splice variant of the alpha-subunit of the heterotrimeric G-protein Gs. It differs from the short splice variant by a 15 amino acid insert between the ras-like domain and the alpha-helical domain.
Cellular localizationADRB2: Cell membrane; Multi-pass membrane protein
References for Recombinant human ADRB2 + GsaL fusion protein (ab90837)
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