Recombinant human ADRB2 GsaS fusion protein (ab90624)

Overview

  • Product nameRecombinant human ADRB2 GsaS fusion protein
  • Protein lengthFull length protein
  • Description
    Recombinant human ADRB2 GsαS fusion protein

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab90624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityActivity: 1.3-7 pmol/mg
  • FormLiquid
  • Additional notes


    ab90624 ensures a defined 1:1 stoichiometry of the receptor and the GsaS subunit as well as high coupling efficiency. ab90624 does not exhibit the hallmarks of constitutive activity, e.g. high efficacies of partial agonists and inverse agonists and AC activation by the agonist-free beta2AR.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • ADRB2
    • ADRB2R
    • ADRBR
    • Adrenergic beta 2 receptor surface
    • B2AR
    • BAR
    • Beta 2 adrenergic receptor
    • Beta 2 adrenoceptor
    • Beta 2 adrenoreceptor
    • BETA2AR
    • Catecholamine receptor
    see all
  • RelevanceBeta adrenergic receptors mediate the catecholamine induced activation of adenylate cyclase through the action of G proteins. The beta 2 adrenergic receptor binds epinephrine with an approximately 30 fold greater affinity than it does norepinephrine. The beta 2 adrenergic receptor is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase (AC) activation. The beta 2 adrenergic receptors are found in numerous tissues and cell types including vascular and bronchial smooth muscle cells, leukocytes and liver. The beta 2 adrenergic receptors mediate smooth muscle relaxation, inhibition of leukocyte function and activation of glycogenolysis. GsaS is the short splice variant of the alpha subunit of the heterotrimeric G protein Gs. Gs activates the effector AC.
  • Cellular localizationCell membrane; Multi pass membrane protein.

References for Recombinant human ADRB2 GsaS fusion protein (ab90624)

ab90624 has not yet been referenced specifically in any publications.

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