The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
ALL 1 fused gene from chromosome 10
ALL1 fused gene from chromosome 10
ALL1-fused gene from chromosome 10 protein
Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog Drosophila) translocated to 10
Myeloid/lymphoid or mixed lineage leukemia translocated to 10
Protein AF 10
Type I AF10 protein
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.
Expressed abundantly in testis.
Involvement in disease
A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.