Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MKHHHHHHHM LVPRGSAQMG LAPMEGIRRP DQALLPELPG LGLRAPLKKT TAEQAEEDLL QEAQALAEVL DLQDREPRSS RRCVRLHESC LGQQVPCCDP CATCYCRFFN AFCYCRKLGT AMNPCSRT
    • Molecular weight
      14 kDa including tags
    • Amino acids
      21 to 132
    • Tags
      His tag N-Terminus
    • Additional sequence information
      16 amino acid N-terminal His Tag, thrombin cleavage site. The peptide contains the propeptide and mature peptide, and the signal peptide has been cleaved.

Specifications

Our Abpromise guarantee covers the use of ab186691 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    >95% by SDS-PAGE .
    ab186691 was purified by proprietary chromatographic techniques.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Reconstitute for long term storage.

    pH: 7.50
    Constituents: 0.06% Tris, 0.15% Sodium chloride

  • Reconstitution
    Add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.

General Info

  • Alternative names
    • Agouti related neuropeptide
    • Agouti Related Protein Homolog
    • Agouti-related protein
    • Agrp
    • AGRP_HUMAN
    • AGRT
    • ART
    • ASIP2
    see all
  • Function
    Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
  • Tissue specificity
    Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
  • Involvement in disease
    Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • Sequence similarities
    Contains 1 agouti domain.
  • Domain
    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
  • Cellular localization
    Secreted. Golgi apparatus lumen.
  • Information by UniProt

References

ab186691 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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