Recombinant Human AKAP12 protein (ab160562)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      VPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLT KESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERES AKSELTES
    • Amino acids
      1675 to 1782
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160562 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • A kinase (PRKA) anchor protein (gravin) 12
    • A kinase Anchor Protein 12
    • A kinase anchor protein 250kDa
    • A-kinase anchor protein 12
    • A-kinase anchor protein 250 kDa
    • AKA12_HUMAN
    • AKAP 12
    • AKAP 250
    • AKAP-12
    • Akap12
    • AKAP250
    • DKFZp686M0430
    • DKFZp686O0331
    • FLJ20945
    • FLJ97621
    • Gercelin
    • Gravin
    • Kinase scaffold protein gravin
    • Myasthenia gravis autoantigen
    • Myasthenia gravis autoantigen gravin
    • OTTHUMP00000017426
    • OTTHUMP00000017427
    • Src-Suppressed C Kinase Substrate
    • Srcs5
    • SSeCKS
    • Tsga12
    see all
  • Function
    Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
  • Tissue specificity
    Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
  • Sequence similarities
    Contains 3 AKAP domains.
  • Domain
    Polybasic regions located between residues 266 and 557 are involved in binding PKC.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cytoplasm > cell cortex. Cytoplasm > cytoskeleton. May be part of the cortical cytoskeleton.
  • Information by UniProt

Images

  • ab160562 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160562 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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