The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activitySpecific activity: approximately 0.15 - 0.2 units/mg.
Enzymatic activity was confirmed by measuring the amount of enzyme catalyzing the oxidation of 1 micromole NADPH per minute at 25°C. Specific activity was expressed as units/mg protein.
% SDS-PAGE. ab117472 is purified by proprietary chromatographic techniques.
Additional notesab117472 is stable at 4°C for 30 days, it should be stored desiccated below -20°C for periods greater than 30 days. Avoid freeze-thaw cycles.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Please see notes section.
pH: 8.00 Constituents: 0.32% Tris HCl, 0.02% DTT, 20% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
FunctionConverts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Tissue specificityExpressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
Sequence similaritiesBelongs to the aldo/keto reductase family.