Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY
    • Amino acids1 to 323

Specifications

Our Abpromise guarantee covers the use of ab93730 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    Purified by using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8

General Info

  • Alternative names
    • 2-dihydrobenzene-1
    • 2-diol dehydrogenase
    • 20 alpha (3 alpha) hydroxysteroid dehydrogenase
    • 20 ALPHA HSD
    • 20 alpha hydroxysteroid dehydrogenase
    • 20-alpha-HSD
    • 20-alpha-hydroxysteroid dehydrogenase
    • 20ALPHAHSD
    • 2ALPHAHSD
    • AK1C1
    • AK1C1_HUMAN
    • AKR1C1
    • Aldo keto reductase family 1 member C1
    • aldo-keto reductase C
    • Aldo-keto reductase family 1 member C1
    • Aldo-keto reductase family, 1 member 1
    • C9
    • Chlordecone reductase homolog
    • Chlordecone reductase homolog HAKRC
    • DD1
    • DD1/DD2
    • DDH
    • DDH1
    • Dihydrodiol dehydrogenase 1
    • Dihydrodiol dehydrogenase 1/2
    • dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase
    • dihydrodiol dehydrogenase isoform DD1
    • Dihydrodiol dehydrogenase, type 1
    • H37
    • HAKRC
    • HBAB
    • Hepatic dihydrodiol dehydrogenase
    • High affinity hepatic bile acid-binding protein
    • High-affinity hepatic bile acid-binding protein
    • Indanol dehydrogenase
    • MBAB
    • MGC8954
    • Trans-1
    • Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase
    • Type II 3 alpha hydroxysteroid dehydrogenase
    see all
  • FunctionConverts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
  • Tissue specificityExpressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
  • Sequence similaritiesBelongs to the aldo/keto reductase family.
  • Cellular localizationCytoplasm.
  • Information by UniProt

Recombinant Human AKR1C1 protein images

  • 15% SDS Page analysis of ab93730 (3 µg).
  • Anti-AKR1C1/AKR1C2 antibody (ab96087) at 1/1000 dilution + Recombinant Human AKR1C1 protein (ab93730) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 10 seconds

References for Recombinant Human AKR1C1 protein (ab93730)

ab93730 has not yet been referenced specifically in any publications.

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