Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD RNLHYFNSDS FASHPNYPYS DEY

Specifications

Our Abpromise guarantee covers the use of ab87417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab87417 is purified using conventional chromatography techniques.
  • FormLiquid
  • Additional notesEndotoxin: < 1.0 EU per 1 µg of protein (determined by LAL method).
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0

General Info

  • Alternative names
    • 17 beta HSD 5
    • 17 beta hydroxysteroid dehydrogenase type 5
    • 17-beta-HSD 5
    • 17-beta-hydroxysteroid dehydrogenase type 5
    • 2-dihydrobenzene-1
    • 2-diol dehydrogenase
    • 20-alpha-hydroxysteroid dehydrogenase
    • 3 alpha hydroxysteroid dehydrogenase type II
    • 3-alpha-HSD type 2
    • 3-alpha-HSD type II
    • 3-alpha-HSD type II, brain
    • 3-alpha-hydroxysteroid dehydrogenase type 2
    • AK1C3_HUMAN
    • AKR1 C3
    • Akr1c18
    • AKR1C3
    • Aldo keto reductase family 1 member C3
    • Aldo-keto reductase family 1 member C3
    • brain
    • Chlordecone reductase
    • Chlordecone reductase homolog HAKRb
    • DD-3
    • DD3
    • DDH1
    • DDX
    • Dihydrodiol dehydrogenase 3
    • Dihydrodiol dehydrogenase type I
    • Dihydrodiol dehydrogenase X
    • HA1753
    • HAKRB
    • HAKRe
    • hluPGFS
    • HSD17B5
    • Indanol dehydrogenase
    • KIAA0119
    • PGFS
    • Prostaglandin F synthase
    • Testosterone 17-beta-dehydrogenase 5
    • Trans-1
    • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    • Type IIb 3 alpha hydroxysteroid dehydrogenase
    see all
  • FunctionCatalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
  • Tissue specificityExpressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
  • Sequence similaritiesBelongs to the aldo/keto reductase family.
  • Cellular localizationCytoplasm.
  • Information by UniProt

Recombinant Human AKR1C3 protein images

  • 15% SDS-PAGE showing 3µg ab87417 at approximately 39kDa.

References for Recombinant Human AKR1C3 protein (ab87417)

ab87417 has not yet been referenced specifically in any publications.

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