The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab87417 is purified using conventional chromatography techniques.
Additional notesEndotoxin: < 1.0 EU per 1 µg of protein (determined by LAL method).
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
17 beta HSD 5
17 beta hydroxysteroid dehydrogenase type 5
17-beta-hydroxysteroid dehydrogenase type 5
3 alpha hydroxysteroid dehydrogenase type II
3-alpha-HSD type 2
3-alpha-HSD type II
3-alpha-HSD type II, brain
3-alpha-hydroxysteroid dehydrogenase type 2
Aldo keto reductase family 1 member C3
Aldo-keto reductase family 1 member C3
Chlordecone reductase homolog HAKRb
Dihydrodiol dehydrogenase 3
Dihydrodiol dehydrogenase type I
Dihydrodiol dehydrogenase X
Prostaglandin F synthase
Testosterone 17-beta-dehydrogenase 5
Type IIb 3 alpha hydroxysteroid dehydrogenase
FunctionCatalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Tissue specificityExpressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
Sequence similaritiesBelongs to the aldo/keto reductase family.