Additional sequence informationAKR7A3 Human Recombinant fused to 39 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 370 amino acids (1-331 a.a.).
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activitySpecific activity: approximately < 0.1 units/mg.
Enzymatic activity was confirmed by measuring the amount of enzyme catalyzing the oxidation of 1 micromole NADPH per minute at 25C. Specific activity was expressed as units/mg protein.
% SDS-PAGE. ab116489 was purified by proprietary chromatographic techniques and filter sterilized.
Additional notes although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
AFB1 aldehyde reductase 2
AFB1 AR 2
Aflatoxin aldehyde reductase
Aflatoxin B1 aldehyde reductase 2
Aflatoxin B1 aldehyde reductase member 3
Aldo keto reductase family 7 member A3
FunctionCan reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Tissue specificityExpressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.
Sequence similaritiesBelongs to the aldo/keto reductase 2 family.