Recombinant human ALDH3A1 protein (ab168020)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNAVVLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH
    • Molecular weight
      53 kDa including tags
    • Amino acids
      1 to 453
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab168020 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity is > 0.5 units/ml, and was obtained by measuring the increase of NADP in absorbance at 340 nm resulting from the reduction of NAD. One unit will oxidize 1.0 µmole of acetaldehyde to acetic acid per minute at pH 8.0 at 25°C in the presence of beta-NAD, potassium and thiols.
  • Applications

    SDS-PAGE

    Functional Studies

  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Additional notes
    Centrifuge the vial prior to opening
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Acetaldehyde dehydrogenase 3
    • AHD 4
    • AHD C
    • AHD4
    • AHDC
    • AL3A1_HUMAN
    • Aldehyde dehydrogenase
    • Aldehyde dehydrogenase 3
    • Aldehyde dehydrogenase 3 family member A1
    • Aldehyde dehydrogenase 3A1
    • Aldehyde dehydrogenase class 3
    • Aldehyde dehydrogenase dimeric NADP preferring
    • Aldehyde dehydrogenase family 3 member A1
    • Aldehyde dehydrogenase family 3 subfamily A1
    • Aldehyde dehydrogenase family 3, subfamily A, member 1
    • Aldehyde dehydrogenase isozyme 3
    • Aldehyde dehydrogenase type III
    • ALDH 3
    • ALDH 3A1
    • ALDH III
    • ALDH, stomach type
    • ALDH3
    • ALDH3 A1
    • ALDH3A 1
    • Aldh3a1
    • ALDHIII
    • dimeric NADP-preferring
    • MGC10406
    • Stomach aldehyde dehydrogenase
    • Tumor associated aldehyde dehydrogenase tumor ALDH
    see all
  • Function
    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.
  • Tissue specificity
    High levels in stomach, esophagus and lung; low level in the liver and kidney.
  • Sequence similarities
    Belongs to the aldehyde dehydrogenase family.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3 µg ab168020.

References

ab168020 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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