Recombinant Human ALDH4A1 protein (ab160138)

Overview

  • Product name
    Recombinant Human ALDH4A1 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDAL QKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKS LLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVG QGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGL EGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILR EAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSA CSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARI KKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFG PVLSVYVYPDDKYKETLQLIDSTTSYGLTGAVFSQDKDVVQEATKVLRNA AGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKET HKPLGDWSYAYMQ
    • Amino acids
      1 to 563
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • AL4A1_HUMAN
    • aldehyde dehydrogenase 4
    • aldehyde dehydrogenase 4 family, member A1
    • Aldehyde dehydrogenase family 4 member A1
    • Aldehyde dehydrogenase, family 4, subfamily A, member 1
    • ALDH4
    • aldh4a1
    • Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial
    • Delta-1-pyrroline-5-carboxylate dehydrogenase
    • L-glutamate gamma-semialdehyde dehydrogenase
    • mitochondrial
    • mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase
    • P5C dehydrogenase
    • P5CD
    • P5CDh
    • P5CDhL
    • P5CDhS
    • Pyrroline-5-carboxylate dehydrogenase
    • RP11 128M10.1
    see all
  • Function
    Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
  • Tissue specificity
    Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
  • Pathway
    Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.
  • Involvement in disease
    Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2) [MIM:239510]. HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation.
  • Sequence similarities
    Belongs to the aldehyde dehydrogenase family.
  • Cellular localization
    Mitochondrion matrix.
  • Information by UniProt

Images

  • ab160138 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160138 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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