The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
competitive binding assays
Additional notesThis product is an aliquot of membranes from Sf9 cells transfected with the human recombinant alpha 2a Adrenergic Receptor.
The membranes will retain their original specific activity for several months when stored at -80 °C in the original packing solution.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Adrenergic alpha 2A receptor
Alpha 2 adrenergic receptor subtype C10
Alpha 2A adrenergic receptor
Alpha 2AAR subtype C10
Alpha-2 adrenergic receptor subtype C10
alpha-2-adrenergic receptor, platelet type
Alpha-2A adrenergic receptor
FunctionAlpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.