This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Involvement in disease
Dystonia 12 Alternating hemiplegia of childhood 2 Cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.