Recombinant Human alpha Actinin 4 protein (ab126006)

Overview

  • Product nameRecombinant Human alpha Actinin 4 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionO43707
    • SpeciesHuman
    • Molecular weight29 kDa
    • Amino acids397 to 648

Specifications

Our Abpromise guarantee covers the use of ab126006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • ReconstitutionReconstitute with water to desired concentration.

General Info

  • Alternative names
    • actinin 4
    • Actinin alpha 4
    • actinin4
    • ACTN 4
    • ACTN4
    • ACTN4_HUMAN
    • Alpha-actinin-4
    • DKFZp686K23158
    • F actin cross linking protein
    • F-actin cross-linking protein
    • Focal segmental glomerulosclerosis 1
    • FSGS
    • FSGS 1
    • FSGS1
    • Non muscle alpha actinin 4
    • Non-muscle alpha-actinin 4
    see all
  • FunctionF-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
  • Tissue specificityWidely expressed.
  • Involvement in diseaseDefects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1) [MIM:603278]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • Sequence similaritiesBelongs to the alpha-actinin family.
    Contains 1 actin-binding domain.
    Contains 2 CH (calponin-homology) domains.
    Contains 2 EF-hand domains.
    Contains 4 spectrin repeats.
  • Cellular localizationNucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines.
  • Information by UniProt

References for Recombinant Human alpha Actinin 4 protein (ab126006)

ab126006 has not yet been referenced specifically in any publications.

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