FunctionMay contribute to the transparency and refractive index of the lens.
Tissue specificityLens as well as other tissues.
Involvement in diseaseDefects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.
Sequence similaritiesBelongs to the small heat shock protein (HSP20) family.
Cellular localizationCytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Recombinant Human Alpha B Crystallin protein images
SDS-PAGE - Human Alpha B Crystallin full length protein (ab113180)
SDS-PAGE analysis: Lane 1: MWM, Lane 2: 1μg ab113180, Lane 3: 2μg ab113180, Lane 4: 5μg ab113180.
Western blot - Human Alpha B Crystallin full length protein (ab113180)
Western Blot analysis: Lane 1: MW marker, Lane 2: ab113180, Lane 3: bovine native alpha A Crystallin, Lane 4: bovine native Alpha B crystallin. Left: probed with Alpha B crystallin antibody. Right: probed with alpha A crystallin antibody.
References for Recombinant Human Alpha B Crystallin protein (ab113180)
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