The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Augmenter of liver regeneration
Erv1 like growth factor
FAD-linked sulfhydryl oxidase ALR
Growth factor augmenter of liver regeneration
Growth factor erv1 like
Hepatic regenerative stimulation substance
Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.
Involvement in disease
Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD) [MIM:613076]; also called combined mitochondrial complex deficiency.
Contains 1 ERV/ALR sulfhydryl oxidase domain.
Mitochondrion intermembrane space and Cytoplasm. Secreted.