Overview

  • Product nameRecombinant Human AMFR protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionQ9UKV5
    • SpeciesHuman
    • SequenceQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQV PFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLD
    • Molecular weight37 kDa including tags
    • Amino acids451 to 550

Associated products

Specifications

Our Abpromise guarantee covers the use of ab114887 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • AMF receptor
    • AMF receptor isoform 1
    • AMF receptor isoform 2
    • AMFR
    • AMFR2_HUMAN
    • Autocrine motility factor receptor
    • Autocrine motility factor receptor precursor, isoform 1
    • Autocrine motility factor receptor precursor, isoform 2
    • E3 ubiquitin-protein ligase AMFR
    • gp78
    • isoform 2
    • RING finger protein 45
    • RNF 45
    • RNF45
    see all
  • FunctionE3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesContains 1 CUE domain.
    Contains 1 RING-type zinc finger.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt

Recombinant Human AMFR protein images

  • 12.5% SDS-PAGE showing ab114887 at approximately 36.63kDa.
    Stained with Coomassie Blue.

References for Recombinant Human AMFR protein (ab114887)

ab114887 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"