This product is an active protein and may elicit a biological response in vivo, handle with caution.
5' AMP activated protein kinase beta 1 subunit
5' AMP activated protein kinase subunit beta 1
5' AMP activated protein kinase subunit gamma 3
5' AMP activated protein kinase, catalytic alpha 2 chain
5' AMP activated protein kinase, gamma 3 subunit
5'-AMP-activated protein kinase catalytic subunit alpha-2
Acetyl CoA carboxylase kinase
AMP activated protein kinase alpha 2 subunit variant 2
AMP activated protein kinase alpha 2 subunit variant 3
AMP activated protein kinase beta subunit
AMPK alpha 2 chain
AMPK beta 1 chain
AMPK beta 1
AMPK gamma 3 chain
AMPK subunit alpha 2
AMPK subunit beta 1
AMPK subunit gamma 3
Hydroxymethylglutaryl CoA reductase kinase
Protein kinase, AMP activated, gamma 3 non catalytic subunit
Protein kinase, AMP activated, noncatalytic, beta 1
Protein kinase, AMP-activated, alpha 2 catalytic subunit
Protein kinase, AMP-activated, beta 1 non-catalytic subunit
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Cytoplasmic and Nuclear
Functional Studies - Active human AMPK alpha 2 + AMPK beta 1 +AMPK gamma 3 full length protein (ab184881)
The specific activity of ab184881 was determined to be 360 nmol/min/mg.
SDS-PAGE - Active human AMPK alpha 2 + AMPK beta 1 +AMPK gamma 3 full length protein (ab184881)
ab184881 was determined to be >90% pure by densitometry.
has not yet been referenced specifically in any publications.
Publishing research using ab184881? Please let us know so that we can cite the reference in this datasheet.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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