Recombinant Human Angiogenin protein (ab114413)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNK RSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGF RNVVVACENGLPVHLDQSIFRRP
    • Molecular weight
      40 kDa including tags
    • Amino acids
      25 to 147

Specifications

Our Abpromise guarantee covers the use of ab114413 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    SDS-PAGE

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • ALS9
    • AMYOTROPHIC LATERAL SCLEROSIS
    • ANG
    • ANG 1
    • ANG I
    • ANG1
    • ANGI
    • ANGI_HUMAN
    • Angiogenin
    • Angiogenin ribonuclease RNase A family, 5
    • Epididymis luminal protein 168
    • HEL168
    • MGC22466
    • MGC71966
    • Ribonuclease 5
    • Ribonuclease RNase A Family 5
    • RNase 5
    • RNASE4
    • RNASE5
    see all
  • Function
    May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
  • Tissue specificity
    Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
  • Involvement in disease
    Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.
  • Sequence similarities
    Belongs to the pancreatic ribonuclease family.
  • Developmental stage
    Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.
  • Cellular localization
    Secreted.
  • Information by UniProt

Images

  • ab114413 analysed by a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab114413 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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