Recombinant human Angiopoietin-like 4 protein (ab108558)



  • NatureRecombinant
  • SourceHEK 293 cells
  • Amino Acid Sequence
    • AccessionQ9BY76
    • SpeciesHuman
    • Molecular weight18 kDa including tags
    • Amino acids1 to 161
    • TagsDDDDK tag C-Terminus


Our Abpromise guarantee covers the use of ab108558 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityActivates ERK phosphorylation in THP-1 cells.
  • Applications


    Functional Studies

  • Endotoxin level< 0.100 Eu/µg
  • Purity> 90 % SDS-PAGE.
    ab108558 is 0.2 µm filtered.
  • FormLiquid
  • Additional notesWorking aliquots are stable for up to 3 months when stored at -20°C.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Angiopoietin like 4
    • Angiopoietin related protein 4
    • Angiopoietin-like protein 4
    • Angiopoietin-related protein 4
    • ANGPT L2
    • ANGPT L4
    • ANGPTL2
    • Angptl4
    • ARP4
    • Fasting induced adipose factor
    • FIAF
    • HARP
    • Hepatic angiopoietin related protein
    • Hepatic fibrinogen/angiopoietin related protein
    • Hepatic fibrinogen/angiopoietin-related protein
    • HFARP
    • NL2
    • Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein
    • PGAR
    • pp1158
    • PPARG angiopoietin related protein
    • PSEC0166
    • TGQTL
    • UNQ171
    • Weakly similar to angiopoietin 1 [H.sapiens]
    see all
  • FunctionProtein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
  • Tissue specificityExpressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
  • Sequence similaritiesContains 1 fibrinogen C-terminal domain.
  • Post-translational
  • Cellular localizationSecreted. Secreted > extracellular space > extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
  • Information by UniProt

Recombinant human Angiopoietin-like 4 protein images

  • ERK phosphorylation induced by ab108558 (hANGPTL4 - coiled-coil domain) in THP-1 cells.
    A. THP-1 monocyte cells were serum starved for 16 hr and then stimulated with ab108558 (500 ng/ml) for 1, 2 and 3 hrs, respectively. Antibodies against pERK1/2 and total ERK1/2 were used for immunoblotting.
    B. Cells were treated with 20 µM PD98058 (MEK inhibitor) for 30 min prior adding of 500 ng/ml ab108558. After 3 hrs of incubation, Western blot was performed.

References for Recombinant human Angiopoietin-like 4 protein (ab108558)

ab108558 has not yet been referenced specifically in any publications.

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