Recombinant Human Angiopoietin-like 4 protein (ab153331)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      GPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSA CGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLFHKVAQ QQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPA HNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWT VIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAV QLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVP FSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQKLK KGIFWKTWRGRYHPLQATTMLIQPIAAEAAS
    • Amino acids
      26 to 406
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153331 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Angiopoietin like 4
    • Angiopoietin related protein 4
    • Angiopoietin-like protein 4
    • Angiopoietin-related protein 4
    • ANGL4_HUMAN
    • ANGPT L2
    • ANGPT L4
    • ANGPTL2
    • Angptl4
    • ARP4
    • Fasting induced adipose factor
    • FIAF
    • HARP
    • Hepatic angiopoietin related protein
    • Hepatic fibrinogen/angiopoietin related protein
    • Hepatic fibrinogen/angiopoietin-related protein
    • HFARP
    • NL2
    • Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein
    • PGAR
    • pp1158
    • PPARG angiopoietin related protein
    • PSEC0166
    • TGQTL
    • UNQ171
    • Weakly similar to angiopoietin 1 [H.sapiens]
    see all
  • Function
    Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
  • Tissue specificity
    Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
  • Sequence similarities
    Contains 1 fibrinogen C-terminal domain.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Secreted. Secreted > extracellular space > extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
  • Information by UniProt

Images

  • ab153331 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153331 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab153331.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up