ReconstitutionAdd deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely.
Angiopoietin like 4
Angiopoietin related protein 4
Angiopoietin-like protein 4
Angiopoietin-related protein 4
Fasting induced adipose factor
Hepatic angiopoietin related protein
Hepatic fibrinogen/angiopoietin related protein
Hepatic fibrinogen/angiopoietin-related protein
Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein
PPARG angiopoietin related protein
Weakly similar to angiopoietin 1 [H.sapiens]
FunctionProtein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
Tissue specificityExpressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Cellular localizationSecreted. Secreted > extracellular space > extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.