Recombinant Human Angiotensinogen protein (ab114529)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP01019
    • SpeciesHuman
    • SequenceTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVL NSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFL GRVANPLSTA
    • Molecular weight38 kDa including tags
    • Amino acids376 to 485

Specifications

Our Abpromise guarantee covers the use of ab114529 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • Aangiotensinogen (serpin peptidase inhibitor clade A member 8)
    • AGT
    • AI265500
    • Alpha 1 antiproteinase antitrypsin
    • Ang
    • Ang I
    • Ang II
    • Ang III
    • AngII
    • Angiotensin I
    • Angiotensin II
    • Angiotensin III
    • Angiotensin-3
    • Angiotensinogen
    • Angiotensinogen (PAT)
    • ANGT_HUMAN
    • ANHU
    • ANRT
    • AT-2
    • AT-II
    • Des-Asp[1]-angiotensin II
    • FLJ92595
    • FLJ97926
    • MGC105326
    • PAT
    • Pre angiotensinogen
    • Serine (or cysteine) proteinase inhibitor
    • Serpin A8
    • Serpin peptidase inhibitor clade A member 8
    • SERPINA8
    see all
  • FunctionEssential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.
    Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
    Angiotensin-3 stimulates aldosterone release.
    Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
  • Tissue specificityExpressed by the liver and secreted in plasma.
  • Involvement in diseaseGenetic variations in AGT are a cause of susceptibility to essential hypertension (EHT) [MIM:145500]. Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.
    Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
  • Sequence similaritiesBelongs to the serpin family.
  • Post-translational
    modifications
    Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
  • Cellular localizationSecreted.
  • Information by UniProt

Recombinant Human Angiotensinogen protein images

  • 12.5% SDS-PAGE analysis of Human Angiotensinogen protein (ab114529). Stained with Coomassie Blue.

References for Recombinant Human Angiotensinogen protein (ab114529)

ab114529 has not yet been referenced specifically in any publications.

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