Recombinant Human ANKRD1 protein (ab134543)
Key features and details
- Expression system: Escherichia coli
- Purity: > 85% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: MS, SDS-PAGE
Description
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Product name
Recombinant Human ANKRD1 protein -
Purity
> 85 % SDS-PAGE.
ab134543 is purified using conventional chromatography techniques. -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MGSSHHHHHHSSGLVPRGSHMGSMMVLKVEELVTGKKNGNGEAGEFLPED FRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQ RSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKA ALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGA QIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAV RTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGAD LNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF -
Predicted molecular weight
39 kDa including tags -
Amino acids
1 to 319 -
Tags
His tag N-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab134543 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Mass Spectrometry
SDS-PAGE
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Mass spectrometry
MALDI-TOF -
Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.50
Constituents: 0.08% DTT, 0.32% Tris HCl, 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride
General Info
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Alternative names
- ALRP
- ANKR1_HUMAN
- ANKRD 1
see all -
Function
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. -
Tissue specificity
Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells. -
Involvement in disease
Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births. -
Sequence similarities
Contains 5 ANK repeats. -
Cellular localization
Nucleus. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab134543 has not yet been referenced specifically in any publications.