Recombinant Human ANKS1B protein (ab163417)

Overview

  • Product name
    Recombinant Human ANKS1B protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MMWQCHPSAQDYRYYPVDGYSLLKRFPLHPLTGPRCPVQTVGQWLESIGL PQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLP KMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVEL INVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLS PSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQSS VCEIWTNQNAGFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYWQH HPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMK KVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYIT KDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSST LPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVEPGQEAKRG INTKYETTIF
    • Amino acids
      1 to 510
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • AIDA
    • AIDA-1
    • Amyloid-beta protein intracellular domain-associated protein 1
    • Anks1b
    • ANKS2
    • Ankyrin repeat and sterile alpha motif domain containing 1B
    • Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    • ANS1B_HUMAN
    • Cajalin 2
    • E2A-PBX1-associated protein
    • EB-1
    • EB1
    • MGC26087
    see all
  • Function
    Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
    Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
    Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
  • Tissue specificity
    Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
  • Sequence similarities
    Contains 7 ANK repeats.
    Contains 1 PID domain.
    Contains 2 SAM (sterile alpha motif) domains.
  • Post-translational
    modifications
    Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage.
  • Cellular localization
    Cytoplasm; Nucleus; Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Nucleus. Nucleus > Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner and Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.
  • Information by UniProt

Images

  • ab163417 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163417 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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