Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLT AQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPIN KRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLAT YSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQEL LRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMC YKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEH DQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPE DPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNN LGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVD YFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVH TMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF EIEMNESDMMLETSMSDHST
    • Amino acids
      1 to 620
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160243 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • ANAPC6
    • Anaphase promoting complex subunit 6
    • Anaphase-promoting complex subunit 6
    • Apc 6
    • APC6
    • CDC 16
    • Cdc16
    • CDC16 (cell division cycle 16 S. cerevisiae homolog)
    • CDC16 homolog
    • CDC16 protein
    • CDC16_HUMAN
    • CDC16Hs
    • Cell division cycle 16
    • Cell division cycle 16 homolog
    • Cell division cycle protein 16 homolog
    • CUT9
    • Cyclosome subunit 6
    see all
  • Function
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the APC6/CDC16 family.
    Contains 7 TPR repeats.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
  • Cellular localization
    Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
  • Information by UniProt

Images

  • ab160243 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160243 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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