Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLT AQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPIN KRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLAT YSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQEL LRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMC YKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEH DQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPE DPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNN LGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVD YFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVH TMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF EIEMNESDMMLETSMSDHST
    • Amino acids
      1 to 620
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160243 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • ANAPC6
    • Anaphase promoting complex subunit 6
    • Anaphase-promoting complex subunit 6
    • Apc 6
    • APC6
    • CDC 16
    • Cdc16
    • CDC16 (cell division cycle 16 S. cerevisiae homolog)
    • CDC16 homolog
    • CDC16 protein
    • CDC16_HUMAN
    • CDC16Hs
    • Cell division cycle 16
    • Cell division cycle 16 homolog
    • Cell division cycle protein 16 homolog
    • CUT9
    • Cyclosome subunit 6
    see all
  • Function
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the APC6/CDC16 family.
    Contains 7 TPR repeats.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
  • Cellular localization
    Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
  • Information by UniProt

Images

  • ab160243 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160243 has not yet been referenced specifically in any publications.

Publishing research using ab160243? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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