The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab116469 is purified by proprietary chromatographic techniques.
Although stable 4°C for 4 weeks, ab116469 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Please see notes section.
pH: 8.00 Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
Involvement in disease
Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD) [MIM:102600]; also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones.
Belongs to the purine/pyrimidine phosphoribosyltransferase family.